Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1417)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1045767	0.1125700	0.3634489
Weighted median	23	-0.0198987	0.0612878	0.7454262
Inverse variance weighted	23	-0.0739823	0.0430760	0.0858908
Simple mode	23	-0.0684482	0.1037658	0.5163305
Weighted mode	23	-0.0198940	0.0811071	0.8085124

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.70749	21	0.1807463
Inverse variance weighted	26.81837	22	0.2182064

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018788	0.006363	0.7706878

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009215	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8