Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1416)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0103074	0.0998212	0.9187372
Weighted median	23	0.0020562	0.0547000	0.9700136
Inverse variance weighted	23	0.0137002	0.0390157	0.7254796
Simple mode	23	0.0087062	0.0888062	0.9227910
Weighted mode	23	-0.0026856	0.0615725	0.9656027

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.96886	21	0.8709332
Inverse variance weighted	14.03713	22	0.9001561

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014743	0.0056424	0.7964133

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004291	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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