Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1415)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0089760	0.0998210	0.9292020
Weighted median	23	-0.0243189	0.0541985	0.6536474
Inverse variance weighted	23	0.0020242	0.0390157	0.9586237
Simple mode	23	-0.0528903	0.0912623	0.5681114
Weighted mode	23	-0.0403704	0.0579798	0.4935421

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.29482	21	0.8078732
Inverse variance weighted	15.30054	22	0.8490205

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004269	0.0056424	0.9404041

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004637	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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