Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1414)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0829926	0.1229249	0.5069476
Weighted median	23	-0.0684024	0.0586226	0.2432802
Inverse variance weighted	23	-0.0205542	0.0472805	0.6637582
Simple mode	23	0.0002197	0.1032983	0.9983220
Weighted mode	23	-0.0769335	0.0708267	0.2891403

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.84665	21	0.0606759
Inverse variance weighted	32.30847	22	0.0722870

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038343	0.0069483	0.5868854

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009874	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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