Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1413)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1308964	0.1155466	0.2700479
Weighted median	23	-0.0562620	0.0656980	0.3917914
Inverse variance weighted	23	-0.0362712	0.0466473	0.4368265
Simple mode	23	-0.1253633	0.1231623	0.3198034
Weighted mode	23	-0.0508835	0.0959869	0.6013461

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.13877	21	0.1362594
Inverse variance weighted	31.44913	22	0.0872849

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0102658	0.0065313	0.1309452

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009791	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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