Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1412)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0608475	0.1207178	0.6194756
Weighted median	23	-0.0024086	0.0621088	0.9690651
Inverse variance weighted	23	0.0003294	0.0464303	0.9943387
Simple mode	23	0.0423121	0.1105589	0.7056065
Weighted mode	23	-0.0168773	0.0760077	0.8263253

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.71369	21	0.0785568
Inverse variance weighted	31.15703	22	0.0929467

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0037569	0.0068236	0.5877355

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009441	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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