Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1411)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0116363	0.1038598	0.9118569
Weighted median	23	-0.0178352	0.0569576	0.7541818
Inverse variance weighted	23	-0.0385260	0.0399203	0.3345085
Simple mode	23	-0.0075528	0.1003247	0.9406696
Weighted mode	23	-0.0221322	0.0716258	0.7602306

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.73428	21	0.3583082
Inverse variance weighted	23.03235	22	0.3999049

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030805	0.0058707	0.6052717

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007275	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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