Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1410)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1486294	0.0998200	0.1513593
Weighted median	23	-0.1072552	0.0558976	0.0550120
Inverse variance weighted	23	-0.0995701	0.0390154	0.0107084
Simple mode	23	-0.0431024	0.0879363	0.6288771
Weighted mode	23	-0.1026828	0.0639536	0.1226254

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.14253	21	0.9035494
Inverse variance weighted	13.42764	22	0.9205443

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030127	0.0056423	0.5989815

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006043	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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