Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 141)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0596956	0.0998204	0.5562153
Weighted median	23	0.0265723	0.0557810	0.6338121
Inverse variance weighted	23	0.0201665	0.0390155	0.6052365
Simple mode	23	0.1051887	0.1022847	0.3149404
Weighted mode	23	0.0496724	0.0715292	0.4946780

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.26041	21	0.6324706
Inverse variance weighted	18.44550	22	0.6792721

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024275	0.0056423	0.6714145

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005671	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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