Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1409)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0364614	0.0998213	0.7185655
Weighted median	23	-0.0318308	0.0531943	0.5495819
Inverse variance weighted	23	-0.0044240	0.0390158	0.9097219
Simple mode	23	-0.0479448	0.0851721	0.5791839
Weighted mode	23	0.0377683	0.0639033	0.5605283

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.75120	21	0.8352258
Inverse variance weighted	14.94921	22	0.8644084

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025108	0.0056424	0.6608846

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004534	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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