Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1408)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0572237	0.0998212	0.5725554
Weighted median	23	-0.0405989	0.0545664	0.4568604
Inverse variance weighted	23	-0.0249339	0.0390159	0.5227779
Simple mode	23	-0.0359765	0.0901322	0.6936288
Weighted mode	23	-0.0468258	0.0619143	0.4574922

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.10390	21	0.9607249
Inverse variance weighted	11.22741	22	0.9713520

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019829	0.0056424	0.7287649

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003526	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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