Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1407)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1107207	0.1014923	0.2876642
Weighted median	23	0.0206728	0.0569745	0.7167222
Inverse variance weighted	23	-0.0029724	0.0401008	0.9409132
Simple mode	23	-0.0109529	0.0901691	0.9044207
Weighted mode	23	0.0094292	0.0620500	0.8806031

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.70943	21	0.4164169
Inverse variance weighted	23.24062	22	0.3882507

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0069819	0.0057368	0.2370941

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007044	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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