Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1406)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0475408	0.1020160	0.6460037
Weighted median	23	0.0311232	0.0542955	0.5664961
Inverse variance weighted	23	0.0365902	0.0390156	0.3483287
Simple mode	23	0.0531165	0.0904002	0.5628033
Weighted mode	23	0.0531165	0.0641209	0.4163517

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.93394	21	0.4033250
Inverse variance weighted	21.94815	22	0.4629873

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006725	0.0057664	0.9082706

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006917	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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