Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1405)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1008776	0.1091236	0.3657613
Weighted median	23	-0.0278433	0.0576928	0.6293706
Inverse variance weighted	23	-0.0712625	0.0417574	0.0878995
Simple mode	23	0.0753447	0.1114156	0.5059302
Weighted mode	23	-0.0240896	0.0790544	0.7634420

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.09729	21	0.2429751
Inverse variance weighted	25.20118	22	0.2875510

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018187	0.0061682	0.771007

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008647	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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