Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1404)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0299497	0.1102813	0.7886005
Weighted median	23	0.0342189	0.0560577	0.5415818
Inverse variance weighted	23	0.0362566	0.0421171	0.3893194
Simple mode	23	0.0267206	0.1041098	0.7998280
Weighted mode	23	0.0414078	0.0715570	0.5686904

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.63217	21	0.2208226
Inverse variance weighted	25.63689	22	0.2675983

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003873	0.0062336	0.9510453

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000803	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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