Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1403)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2023349	0.1355931	0.1505127
Weighted median	23	-0.0385149	0.0593736	0.5165400
Inverse variance weighted	23	-0.0687025	0.0531734	0.1963415
Simple mode	23	0.0519521	0.1080753	0.6354738
Weighted mode	23	-0.0309062	0.0621914	0.6241513

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.74869	21	0.0105159
Inverse variance weighted	40.86405	22	0.0085534

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0082063	0.0076644	0.2964509

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013322	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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