Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1402)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0159929	0.0998196	0.8742407
Weighted median	23	-0.0444530	0.0607482	0.4643153
Inverse variance weighted	23	-0.0430071	0.0390154	0.2703266
Simple mode	23	0.0143998	0.1092152	0.8963029
Weighted mode	23	-0.0025666	0.0859450	0.9764457

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.54427	21	0.7383339
Inverse variance weighted	16.63072	22	0.7833999

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016589	0.0056423	0.7716297

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005408	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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