Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1401)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0326858	0.1322682	0.8072172
Weighted median	23	-0.0265977	0.0677660	0.6946944
Inverse variance weighted	23	-0.0018607	0.0506067	0.9706696
Simple mode	23	-0.0337349	0.1376033	0.8086044
Weighted mode	23	-0.0520525	0.1378844	0.7094136

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.87405	21	0.0174032
Inverse variance weighted	37.01543	22	0.0235638

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021215	0.0074766	0.7793743

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011217	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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