Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1400)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1137992	0.1196703	0.3524525
Weighted median	23	0.0612944	0.0541187	0.2573850
Inverse variance weighted	23	0.0322817	0.0462905	0.4855710
Simple mode	23	-0.1165802	0.1028865	0.2693723
Weighted mode	23	0.0586543	0.0631562	0.3631137

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.18251	21	0.0883814
Inverse variance weighted	30.96967	22	0.0967378

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005006	0.0067643	0.4674608

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009592	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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