Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 140)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0224120	0.1138687	0.8458584
Weighted median	23	-0.0160329	0.0625485	0.7976981
Inverse variance weighted	23	-0.0056723	0.0435576	0.8963888
Simple mode	23	0.0050539	0.1227154	0.9675207
Weighted mode	23	-0.0406282	0.0989630	0.6853813

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.32808	21	0.1602557
Inverse variance weighted	27.42152	22	0.1956524

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017247	0.0064365	0.79135

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008315	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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