Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 14)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0409029	0.1045802	0.6996523
Weighted median	23	0.0549932	0.0557700	0.3240986
Inverse variance weighted	23	-0.0272757	0.0404104	0.4996969
Simple mode	23	0.0072377	0.1012446	0.9436558
Weighted mode	23	0.0568567	0.0581210	0.3385869

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.05054	21	0.3412898
Inverse variance weighted	23.60116	22	0.3684773

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041868	0.0059114	0.4865672

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00073	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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