Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1399)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0512630	0.0998208	0.6129276
Weighted median	23	0.0071116	0.0561807	0.8992694
Inverse variance weighted	23	-0.0259886	0.0390158	0.5053434
Simple mode	23	-0.0032868	0.0951360	0.9727512
Weighted mode	23	0.0205396	0.0664244	0.7600655

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.24551	21	0.5693941
Inverse variance weighted	19.95243	22	0.5860152

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.004744	0.0056423	0.4099391

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006181	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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