Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1398)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1152670	0.1133490	0.3207645
Weighted median	23	-0.1192925	0.0566560	0.0352429
Inverse variance weighted	23	-0.0826518	0.0433853	0.0567714
Simple mode	23	-0.0963453	0.1103154	0.3918994
Weighted mode	23	-0.1278758	0.0675423	0.0715499

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.07869	21	0.1682636
Inverse variance weighted	27.20471	22	0.2035545

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020029	0.006407	0.7576611

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009603	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8