Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1397)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0679878	0.1252488	0.5929679
Weighted median	23	-0.0162867	0.0612138	0.7901913
Inverse variance weighted	23	-0.0211609	0.0485052	0.6626478
Simple mode	23	0.0109921	0.1050976	0.9176490
Weighted mode	23	0.0194328	0.0665987	0.7731813

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.06244	21	0.0455293
Inverse variance weighted	34.00389	22	0.0490796

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0054746	0.0070796	0.4479705

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010393	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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