Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1396)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0621923	0.0998203	0.5399649
Weighted median	23	0.0085998	0.0574304	0.8809680
Inverse variance weighted	23	0.0131300	0.0390155	0.7364700
Simple mode	23	-0.0138211	0.0903457	0.8798080
Weighted mode	23	0.0001340	0.0718897	0.9985293

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.06482	21	0.9378515
Inverse variance weighted	12.73687	22	0.9402407

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0046256	0.0056424	0.4215425

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003894	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8