Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1395)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0634739	0.0998207	0.5317250
Weighted median	23	-0.0201611	0.0556666	0.7172206
Inverse variance weighted	23	-0.0240466	0.0390157	0.5376759
Simple mode	23	-0.0388200	0.0871643	0.6604071
Weighted mode	23	-0.0038015	0.0675327	0.9556176

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.23520	21	0.8109677
Inverse variance weighted	15.41934	22	0.8436224

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024212	0.0056424	0.6722087

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004788	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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