Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1394)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0489962	0.1095034	0.6591388
Weighted median	23	-0.0012109	0.0609360	0.9841455
Inverse variance weighted	23	0.0041386	0.0420919	0.9216764
Simple mode	23	0.1401638	0.1042572	0.1925172
Weighted mode	23	-0.0135275	0.0633020	0.8327507

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.27161	21	0.2355924
Inverse variance weighted	25.60604	22	0.2689802

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.003263	0.0061897	0.6036013

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007763	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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