Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1393)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0916764	0.1046952	0.3911262
Weighted median	23	0.0312261	0.0562130	0.5785552
Inverse variance weighted	23	-0.0101388	0.0410289	0.8048200
Simple mode	23	0.0902046	0.0981825	0.3681935
Weighted mode	23	0.0426089	0.0626953	0.5038346

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.10108	21	0.3386125
Inverse variance weighted	24.32904	22	0.3302210

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0062525	0.0059179	0.3027259

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007393	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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