Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1392)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0270166	0.0998205	0.7893014
Weighted median	23	-0.0475382	0.0567153	0.4019241
Inverse variance weighted	23	0.0104413	0.0390156	0.7889923
Simple mode	23	-0.0804326	0.1083780	0.4658474
Weighted mode	23	-0.0454559	0.0731452	0.5406919

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.82085	21	0.5326332
Inverse variance weighted	19.85339	22	0.5922101

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010179	0.0056424	0.8585672

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006038	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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