Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1391)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2224092	0.1051129	0.0464699
Weighted median	23	-0.0727864	0.0568116	0.2001273
Inverse variance weighted	23	-0.0453633	0.0432218	0.2939257
Simple mode	23	-0.1312613	0.1093436	0.2427321
Weighted mode	23	-0.1251874	0.0685222	0.0813048

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.28646	21	0.3288972
Inverse variance weighted	26.99961	22	0.2112412

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0108724	0.0059415	0.0814968

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008591	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8