Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1390)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1242956	0.1128098	0.2830104
Weighted median	23	0.1208420	0.0611500	0.0481369
Inverse variance weighted	23	0.0459717	0.0436584	0.2923471
Simple mode	23	0.1553959	0.1186134	0.2036757
Weighted mode	23	0.1614232	0.1051835	0.1391191

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.82187	21	0.1768273
Inverse variance weighted	27.54858	22	0.1911276

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0048099	0.0063766	0.4590423

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008768	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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