Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 139)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0075171	0.1139863	0.9480434
Weighted median	23	0.0913286	0.0642185	0.1549812
Inverse variance weighted	23	0.0257141	0.0436320	0.5556330
Simple mode	23	0.0829727	0.1129206	0.4702293
Weighted mode	23	0.0965895	0.0801983	0.2412394

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.38393	21	0.1585036
Inverse variance weighted	27.51475	22	0.1923249

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020407	0.0064431	0.7545735

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008469	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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