Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1389)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1830254	0.1069135	0.1016451
Weighted median	23	-0.1128869	0.0604061	0.0616508
Inverse variance weighted	23	-0.0734955	0.0420145	0.0802413
Simple mode	23	0.0066095	0.1312661	0.9602966
Weighted mode	23	-0.1808975	0.0846779	0.0440287

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.09198	21	0.2886234
Inverse variance weighted	25.51317	22	0.2731694

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0067263	0.0060434	0.2782815

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008806	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8