Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1388)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1660590	0.1444124	0.2631146
Weighted median	23	-0.0096365	0.0636493	0.8796606
Inverse variance weighted	23	0.0149390	0.0568193	0.7926109
Simple mode	23	-0.1491935	0.1082810	0.1821088
Weighted mode	23	-0.0270750	0.0761740	0.7256481

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.95576	21	0.0023692
Inverse variance weighted	46.66116	22	0.0016244

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0092803	0.0081629	0.2683922

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014183	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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