Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1387)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1385505	0.1031544	0.1935644
Weighted median	23	-0.1195963	0.0569070	0.0355875
Inverse variance weighted	23	-0.0945833	0.0395925	0.0168981
Simple mode	23	-0.1200057	0.0927196	0.2089885
Weighted mode	23	-0.1306835	0.0664837	0.0620870

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.42696	21	0.3752744
Inverse variance weighted	22.65596	22	0.4213689

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027	0.0058308	0.6480814

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008646	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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