Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1386)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1079474	0.0998205	0.2917750
Weighted median	23	0.0002348	0.0532297	0.9964802
Inverse variance weighted	23	-0.0041896	0.0390157	0.9144847
Simple mode	23	-0.0164507	0.0941240	0.8628530
Weighted mode	23	-0.0086503	0.0660499	0.8969929

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.76122	21	0.9458408
Inverse variance weighted	13.03649	22	0.9321387

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0063718	0.0056423	0.2715162

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003954	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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