Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1385)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0008827	0.1187489	0.9941394
Weighted median	23	-0.0085945	0.0551801	0.8762274
Inverse variance weighted	23	0.0041361	0.0453489	0.9273282
Simple mode	23	-0.0605341	0.0925767	0.5199653
Weighted mode	23	0.0027192	0.0618999	0.9653574

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.71947	21	0.0977719
Inverse variance weighted	29.72245	22	0.1253678

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003082	0.0067123	0.9638105

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000901	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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