Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1384)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1924431	0.1149691	0.1089877
Weighted median	23	0.1361263	0.0544024	0.0123421
Inverse variance weighted	23	0.1029987	0.0446444	0.0210497
Simple mode	23	0.2086781	0.1083237	0.0670674
Weighted mode	23	0.1754822	0.0644690	0.0124488

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.85939	21	0.1441845
Inverse variance weighted	28.80714	22	0.1504498

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0054928	0.0064987	0.4075128

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010841	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8