Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1383)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0683817	0.1119672	0.5479323
Weighted median	23	0.0286041	0.0605446	0.6366081
Inverse variance weighted	23	0.0890085	0.0450687	0.0482738
Simple mode	23	0.2094405	0.1139433	0.0795879
Weighted mode	23	0.0443326	0.0705807	0.5363967

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.42236	21	0.1908001
Inverse variance weighted	29.35679	22	0.1349534

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0096654	0.006329	0.1416422

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010473	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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