Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1382)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0648730	0.0998203	0.5228048
Weighted median	23	-0.0238479	0.0601792	0.6918975
Inverse variance weighted	23	0.0098905	0.0390155	0.7998815
Simple mode	23	-0.0861991	0.0967692	0.3826913
Weighted mode	23	-0.0523036	0.0632645	0.4172584

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.69779	21	0.5404691
Inverse variance weighted	20.35991	22	0.5605373

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0045912	0.0056423	0.424942

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006189	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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