Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1381)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0566641	0.0998208	0.5762859
Weighted median	23	-0.0004706	0.0573927	0.9934573
Inverse variance weighted	23	-0.0022789	0.0390158	0.9534218
Simple mode	23	-0.0109473	0.0861761	0.9000671
Weighted mode	23	-0.0207411	0.0641908	0.7496585

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.31046	21	0.6921237
Inverse variance weighted	17.66082	22	0.7258983

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0033398	0.0056423	0.5602268

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005353	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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