Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1380)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0104982	0.1125295	0.9265556
Weighted median	23	0.0347744	0.0547573	0.5253863
Inverse variance weighted	23	0.0752400	0.0433696	0.0827665
Simple mode	23	0.1158611	0.0904831	0.2137154
Weighted mode	23	0.0231626	0.0630822	0.7169921

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.68803	21	0.1814194
Inverse variance weighted	27.18455	22	0.2043008

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0039758	0.0063607	0.5386685

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009364	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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