Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 138)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0514121	0.1153468	0.6603630
Weighted median	23	0.0220574	0.0597528	0.7120205
Inverse variance weighted	23	0.0294418	0.0440926	0.5043090
Simple mode	23	-0.0088805	0.0954154	0.9266888
Weighted mode	23	0.0287937	0.0687284	0.6793155

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.04121	21	0.1389863
Inverse variance weighted	28.09839	22	0.1724432

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0013492	0.00652	0.8380555

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008687	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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