Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1379)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2214736	0.1112253	0.0596255
Weighted median	23	0.0634879	0.0597021	0.2875952
Inverse variance weighted	23	-0.0175078	0.0476668	0.7133989
Simple mode	23	0.0161835	0.1100509	0.8844280
Weighted mode	23	0.0441680	0.0711076	0.5408890

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.07311	21	0.2036749
Inverse variance weighted	32.83850	22	0.0641820

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0146757	0.006287	0.0295908

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010011	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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