Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1378)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0402855	0.0998208	0.6906027
Weighted median	23	0.0112965	0.0558925	0.8398294
Inverse variance weighted	23	0.0226827	0.0390157	0.5609885
Simple mode	23	-0.0356246	0.0923975	0.7035272
Weighted mode	23	0.0220643	0.0618085	0.7245090

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.70229	21	0.7861383
Inverse variance weighted	16.17196	22	0.8072604

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038669	0.0056423	0.5006315

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005003	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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