Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1377)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0305903	0.1064030	0.7765515
Weighted median	23	0.0397180	0.0544888	0.4660507
Inverse variance weighted	23	0.0058153	0.0407660	0.8865667
Simple mode	23	0.0088374	0.0993000	0.9298892
Weighted mode	23	0.0410866	0.0630585	0.5214317

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.86128	21	0.2998286
Inverse variance weighted	24.01828	22	0.3462721

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022357	0.0060144	0.7138271

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007285	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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