Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1376)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0714316	0.1096593	0.5218565
Weighted median	23	-0.0235589	0.0613465	0.7009556
Inverse variance weighted	23	-0.0205004	0.0421294	0.6265373
Simple mode	23	-0.0981654	0.1151116	0.4029678
Weighted mode	23	0.0452810	0.1052894	0.6713337

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.34588	21	0.2324948
Inverse variance weighted	25.65318	22	0.2668702

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0031278	0.0061986	0.6191009

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007857	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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