Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1375)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1100945	0.1044675	0.3039205
Weighted median	23	0.0092100	0.0570920	0.8718428
Inverse variance weighted	23	-0.0007205	0.0411354	0.9860260
Simple mode	23	0.0621749	0.0880629	0.4875808
Weighted mode	23	0.0343418	0.0632049	0.5923588

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.00084	21	0.3439338
Inverse variance weighted	24.45549	22	0.3238147

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0068051	0.005905	0.2620924

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007411	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8