Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1374)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0232347	0.1510374	0.8792093
Weighted median	23	-0.0506430	0.0681797	0.4576108
Inverse variance weighted	23	-0.0702671	0.0582946	0.2280573
Simple mode	23	-0.3166070	0.1448793	0.0397999
Weighted mode	23	0.0498191	0.0919563	0.5934229

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.08076	21	0.0006705
Inverse variance weighted	49.11643	22	0.0007710

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0057419	0.0085374	0.5085574

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015866	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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