Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1373)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1858058	0.1407372	0.2009677
Weighted median	23	-0.0762692	0.0642998	0.2355626
Inverse variance weighted	23	-0.0047453	0.0561878	0.9326950
Simple mode	23	-0.1136733	0.1357303	0.4113211
Weighted mode	23	-0.0996990	0.0764551	0.2057064

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.74580	21	0.0045283
Inverse variance weighted	45.62929	22	0.0022064

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0111189	0.0079552	0.1767947

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013831	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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